Floor Plate Derived Tissues

1 developmental biology program sloan kettering institute 1275 york ave new york ny 10065 usa.

Floor plate derived tissues.

Highlights floor plate fp cells can be derived from human embryonic stem cells derivation of fp cells is dependent on an early exposure to high levels of sonic hedgehog the fp generated defaults to an anterior positional identity fp is shifted towards posterior identity in response to wnt and other caudalizing signals. Here we report the efficient derivation of. Little is known about human fp development because of the lack of tissue accessibility. The floor plate fp is a critical signaling center during neural development located along the ventral midline of the embryo.

Here we report the efficient derivation of human embryonic stem cell hesc derived fp tissue capable of secreting netrin 1 and shh and patterning primary and hesc derived tissues. Located on the ventral midline of the embryonic neural tube the floor plate is a specialized glial structure that spans the anteroposterior axis from the midbrain to the tail regions it has been shown that the floor plate is conserved among vertebrates such as zebrafish and mice with homologous. Little is known about human fp development due the lack of tissue accessibility. The study efficient derivation of functional floor plate tissue from human embryonic stem cells was published in the online edition of cell stem cell on april 1 2010 and will also appear in.

The floor plate is a structure integral to the developing nervous system of vertebrate organisms.