15 16 the loss in sensitivity results from a direct inhibitory interaction between the slit receptor roundabout robo and dcc.
Floor plate cues.
Xenopus spinal neurons lose their attraction to netrin 1 following exposure to slit a guidance cue that like netrin 1 is secreted by the floor plate.
These cells partition the distance traveled by growing axons into shorter intervals by serving as intermediate targets orchestrating the arrival and departure of axons by providing attractive and repulsive guidance cues.
Axons have been shown to enter the floor plate as a result of interactions between axonal contactin 2 also known as axonin and neuronal cell adhesion molecule nrcam in the floor plate stoeckli and landmesser 1995.
These experiments suggest that the ability of longitudinal axons to remain.
Same floor plate cues albeit resulting in distinct trajectories.
Lyuksyutova et al 2003.
Was more compact and closest to the floor plate and therefore most likely to be influenced by floor plate cues.
15 the response to a netrin 1 gradient in vitro also depends.
Additional floor plate signals dictate the direction of turns after crossing bourikas et al 2005.
In agreement with this expression pattern wnts are chemoattractive cues in the longitudinal axis of the spinal cord lyuksyutova et al 2003 this attractive response is mediated by the wnt receptor frizzled3 fzd3 since commissural axons of fzd3 mice wang.
When axons arrive at the floor plate short range guidance cues take over.
Summarized by de ramon francàs et al 2017.
Located on the ventral midline of the embryonic neural tube the floor plate is a specialized glial structure that spans the anteroposterior axis from the midbrain to the tail regions it has been shown that the floor plate is conserved among vertebrates such as zebrafish and mice with homologous.
The floor plate repels cultures of longitudinal axons in vitro tamada et al 1995 while certain longitudinal axon bundles wander into the midline in zebrafish lacking floor plate hatta 1992.
The floor plate in the central nervous system cns is a critical intermediate target during neuronal development required.
A candidate guidance cue for postcommissural axons.
We decided to screen for differentially expressed floor plate genes as candidate guidance cues directing commissural axons along the.
Longitudinal axons project through the same environment and thus are potentially influenced by the same floor plate cues albeit resulting in distinct trajectories.
Cues are additionally presented at intermediate points that lie along the axonal trajectory effectively partition ing the pathway of a developing axon into a series of intermediate targets that orchestrate axonal arrival and departure 3.
